Education
M.D. Guangzhou Medical College 1982M.S. Sun Yat-Sen University Medical Sciences 1986
Ph.D. University of Tennessee, Memphis 1990
Postdoc. University of Tennessee, Memphis 1990 -1992
Academic Appointments
Assistant Professor Department of Neurology, University of Tennessee, Memphis 1992-1997
Associate Professor Department of Anatomy & Cell Biology, Indiana University School of Medicine 1998-2004
Professor Department of Anatomy & Cell Biology, Indiana University School of Medicine 2004-Present
Research Interests
Stroke is the third leading cause of death and number one cause of disability in the United States. Neurons in certain regions of the brain (e.g. CA1 pyramidal neurons in hippocampus and medium spiny neurons in neostriatum) are highly vulnerable to transient cerebral ischemia. The mechanisms of such selective cell death following ischemia remain unknown. The long-term goal of this laboratory is to reveal the mechanisms of neuronal damage following cerebral ischemia and provide basis for developing therapeutical interventions. The current projects of this laboratory are investigating the electrophysiological and morphological changes associated with neuronal damage after transient cerebral ischemia in animal models. The research techniques include: intracellular recording and staining in vivo and in vitro; patch-clamped whole-cell or single channel recording in brain slices; quantitative analysis of 3-D reconstructed neurons, light and electron microscopy; immunocytochemistry etc. The results of these studies will improve understanding of the mechanisms of brain damage upon resuscitation following cardiac arrest.
Stroke Research Team
University of Tennessee, Memphis
1992 - 1997
Indiana University School of Medicine
1999
Indiana University School of Medicine
2002
Indiana University School of Medicine Centennial
2003
1. Yubo Ren, M.D. 1994 -1996
Present position: Research Associate, Merck, Montreal, Canada.
2. Xin Zhent Xi, M.D. 1994 -1996,
Present position: Postdoc, Animal Resource, St. Jude Childrenís Hospital, Memphis, TN.
3. Zhi Bin Yao, M.D., Ph.D. 1994 - 1995,
Presnet position: Professor & Chairman, Dept of Anatomy, Sun Yet-Sen Uni Med Sci, Vice mayor of Zhongshan city, P. R. China.
4. Tian Min Gao, M.D., Ph.D. 1995 - 1998,
Present position: Professor and Chairman, Dept. of Physiology, The First Military Med Uni, P. R. China.
5. Yuan Shan Zeng, M.D., Ph.D. 1998 - 1999
Present position: Professor, Dept of Histology, Associate Dean of basic science, Sun Yet-Sen Uni Med Sci, P. R. China.
6. Xian Xuan Chi, Ph.D. 1998 - 2000
Present position: Postdoc, Dept of Pharmacology, IUSM, Indianapolis, IN.
7. M. Gajendiran, Ph.D., 1998 - 2000
Present position: Postdoc, Mental Retardation Research Center, UCLA
8. Guang Yi, Ling, M.D., PH.D., 1999 - 2001
Present position: Postdoc, Dept of Neurology, Washington University at St. Louis.
9. Zhi Ping Pang, M.D. 2000 - 2003
Present position: Graduate Student, Southwestern University, Dallas
10. Yi Wen Ruan, M.D., Ph.D. 2000 - present
11. Ping Deng, M.D., Ph.D. 2001 - present.
12. Bende Zou, M.D., Ph.D. 2002 - 2004
Present position: Postdoc, Dept of Pharmaceutical Chemistry, UCSF
13. Kun Hua, M.D., Ph.D. 2003 - 2004
Present position: Dept. of Neurobiology & Anatomy, Wake Forest University School of Medicine
14. Minfan Wu, M.D., Ph.D. 2003 - Present
15. Zhigang Lei, Ph.D. 2003 - Present
Graduate Student:
1. Eugene Howard Ph.D. (UT, Memphis) 1995 - 2000
2. Yuan Fan, M.D. M.S. 1999 - 2002
3. Yu Chun Zhang, D.D.S. 2002 - Present
4. Yan Li, M.D. 2003 - Present
Representative Publications:
Xu, Z.C., Wilson, C.J. and Emson, P.C. (1989) Restoration of the corticostriatal projection in rat neostriatal grafts: electron microscopic analysis. Neuroscience 29(3): 539-550.
Xu, Z. C., Wilson, C. J. and Emson, P. C. (1991) Restoration of thalamostriatal projections in rat neostriatal grafts: electron microscopic analysis. J. Comp. Neurol. 303:22-34Xu, Z. C., Wilson, C. J. and Emson, P. C. (1991) Synaptic potentials evoked in spiny neurons in rat neostriatal grafts by cortical and thalamic stimulation. J. Neurophysiol. 65(3):477-493.PDF
Xu, Z. C., Wilson, C. J. and Emson, P. C. (1992) Morphology of intracellularly stained spiny neurons in rat striatal graft. Neuroscience 48(1): 95-110.
Xu, Z. C. and Pulsinelli, W. A. (1994) Responses of CA1 pyramidal neurons in rat hippocampus to transient forebrain ischemia: an in vivo intracellular recording study. Neurosci. Lett. 171:187-191
Xu, Z. C. (1995) Neurophysiological changes of spiny neurons in rat neostriatum after transient forebrain ischemia : an in vivo intracellular recording and staining study. Neuroscience 67(4): 823-836.PDF
Xi, X. Z. and Xu, Z. C. (1996) The effect of neurobiotin on membrane properties and morphology of intracellularly labeled neurons. J. Neurosci. Meth. 65:27-32.PDF
Yao, Z. B., Li, Xiaoda and Xu, Z. C. (1996) GABAergic and asymmetric synapses on somata of GABAergic neurons in CA1 and CA3 regions of rat hippocampus: A quantitative electron microscopic study. Stroke 27(8):1411-1415.
Xu, Z. C. and Pulsinelli, W. A. (1996) Neurophysiological changes of CA1 pyramidal neurons following transient forebrain ischemia: An in vivo intracellular recording and staining study. J. Neurophysiol. 76:1689-1698.PDF
Gao, T. M. and Xu, Z. C. (1996) In vivo intracellular demonstration of an ischemia-induced postsynaptic potential from CA1 pyramidal neurons in rat hippocampus. Neuroscience 75:665-669.PDF
Ren, Yubo, Li Xiaoda and Xu, Z. C. (1997) Asymmetrical protection of neostriatal neurons from transient forebrain ischemia by unilateral dopamine depletion. Exp. Neurol. 146:250-257.PDF
Gao, T. M., Pulsinelli, W. A. and Xu, Z. C. (1998) Prolonged poteniation and depression of synaptic transmission in CA1 pyramidal neurons induced by lethal ischemia in vivo. Neuroscience 87:371-383.PDF
Eugene M. Howard, Gao, T. M., Pulsinelli, W. A. and Xu, Z. C. (1998) Electrophysiological changes of CA3 neurons and dentate granule cells following transient forebrain ischemia Brain Res. 798:109-118.PDF
Gao, T. M., Howard, E. M. and Xu, Z. C. (1998) Transient changes in synaptic transmission and membrane properties of CA3 pyramidal neurons and dentate granule cells following severe forebrain ischemia in vivo. J. Neurophysiol. 80:2860-2869.PDF
Gao, T. M., Pulsinelli, W. A. and Xu, Z. C. (1999) The changes of membrane properties in CA1 pyramidal neurons after lethal ischemia in vivo. Neuroscience 90:771-780.PDFXu, Z. C., Gao, T. M. and Ren, Y. (1999) Neurophysiological changes associated with selective neuronal damage in hippocampus following transient forebrain ischemia. Biological Signals and Receptors, 8:294-308.
Xu, Z. C., Chwang W., Li, X., Chen, X. and He, P. (1999) Gender difference in dopamine concentration and postischemic neuronal damage in neostriatum after unilateral dopamine depletion. Exp. Neurol. 158:182-191.PDF
Chi, Xian Xuan and Xu, Z. C. (2000) Increase of potassium current in CA1 neurons of rat hippocampus shortly after transient cerebral ischemia. Neurosci. Lett. 281:5-8.PDF
Zeng, Y. S. and Xu, Z. C. (2000) Co-existence of necrosis and apoptosis in rat hippocampus following transient forebrain ischemia. Neurosci. Res. 37:113-125.
Feng Wei, Zao C. Xu, Zhican Qu, Jeffrey Milbrandt and Min Zhuo (2000) Role of EGR1 in hippocampal synaptic enhancement induced by tetanic stimulation and amputation. J. Cell Biology, 149:1325-1333.PDF
Sun, H. B., Yokota, H., Chi, X. X. and Xu, Z. C. (2000) Differential expression of neurexin mRNA in CA1 and CA3 hippocampal neurons in response to ischemic insult. Mol. Brain Res. 84:146-149.PDF
Chi, X. X. and Xu, Z. C. (2000) Differential changes of potassium currents in CA1 neurons after transient forebrain ischemia. J. Neurophysiol. 84:2834-2843.PDF
Gajendiran M, Ling GY, Pang Z and Xu ZC. (2001) Differential changes of synaptic transmission in spiny neurons of rat neostriatum following transient forebrain ischemia. Neuroscience 105:139-152.PDF
Pang, Z., Ling, G. Y., Gajendiran, M. and Xu, Z. C. (2001) Enhanced excitatory synaptic transmission in spiny neurons after unilateral dopamine denervation: an in vivo intracellular recording study. Neurosci. Lett. 308:201-205. PDF
Chi, X. X. and Xu, Z. C. (2001) Alterations of single potassium channel activity in CA1 pyramidal neurons after transient forebrain ischemia. Neuroscience 108(4): 535-540.PDF
Sun, H. B., Ruan, Y., Xu, Z. C. and Yokota, H. (2002) Involvement of Calcium-Independent Receptor for a-Latrotoxin in brain ischemia. Mol. Brain Res. 104:246-249. PDF
Pang, Z., Ling, G. Y., Gajendiran, M. and Xu, Z. C. (2002) Asymmetrical changes of excitatory synaptic transmission in dopamine denervated striatum after transient forebrain ischemia. Neuroscience 114:317-326.PDF
Pang Z., Deng, P., Ruan, Y. and Xu, Z. C. (2002) Depression of fast excitatory synaptic transmission in large aspiny neurons of neostriatum after transient forebrain ischemia. J. Neurosci. 22: 10948-10957.PDF
Kim, B. O., Liu, Y., Ruan, Y., Xu, Z. C., Schantz, L. and He, J. (2003) Neuropathologies in transgenic mice expressing human immunodeficiency virus type 1 Tat protein under the regulation of the astrocite glial fibrillary acidic pretein promoter and doxycycline. American J. Pathol. 162:1693-1707.PDF
Ruan, Y. W., Ling, G. Y., Zhang, J. L. and Xu, Z.C. (2003) Apoptosis in the adult striatum after transient forebrain ischemia and the effects of ischemic severity. Brain Res. 982:228-240. PDF
Deng, P., Pang, Z. and Xu, Z. C. (2004) Developmental changes of potassium currents in large aspiny neurons in the neostriatum. Dev. Brain Res. 153:97-107.PDF
Fan, Y., Zou, B., Ruan, Y., Pang, Z. P. and Xu, Z. C. (2005) In vivo demonstration of a late depolarizing postsynaptic potential in CA1 neurons. J. Neurophysiol. 93:1326-1335.PDF
Zou, B., Li, Y., Deng, P. and Xu, Z. C. (2005) Alterations of potassium currents in ischemia-vulnerable and ischemia-resistant neurons in the hippocampus after ischemia. Brain Res. 1033:78-89.PDF
Deng, P., Pang, Z., Zhang, Y. and Xu, Z.C. (2005) Increase of delayed rectifier potassium currents in large aspiny neurons in the neostriatum after transient forebrain ischemia. Neuroscience. 131:135-146.PDF
Xu, Z. C., Ling, G., Sahr, R. and Neal-Beliveau, B. (2005) Asymmetrical changes of dopamine receptors in the striatum after unilateral dopamine depletion. Brain Res. 1038:163-170.PDF